COUPLING OF AUTOPHAGY AND THE MITOCHONDRIAL INTRINSIC APOPTOSIS PATHWAY MODULATES PROTEOSTASIS AND AGEING IN CAENORHABDITIS ELEGANS

Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

Abstract Mitochondria preserve metabolic homeostasis and integrate stress signals, to trigger cytoprotective, or cell death pathways.Mitochondrial homeostasis and function decline with age.The mechanisms underlying the deterioration of mitochondrial homeostasis during ageing, or in age-associated Alignment Cam Plate Kit pathologies, remain unclear.

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